Calcium Dysregulation and Melatonin:
See earlier blog entry regarding calcium cell signaling driving sleep entry. Can more answers be found in studying calcium?
This article addresses the use of melatonin in the case of COVID. However, I’m reviewing it because it highlights that melatonin is not only an antiviral, but it seems it can address calcium ion channel dysregulation. A theory is that this dysfunction is what sufferers have in common that contributes to the Hypnic jerking condition.
“Found in erythrocytes, melatonin can reverse hemolytic anemia, normalize heme synthesis, restore lymphocytes and platelet counts, and reduce vessel permeability during an acute hemolytic crisis by maintaining intracellular calcium homeostasis and reduction of oxidative stress. Melatonin normalizes endothelial-dependent nitric oxide production to prevent multiple organ damage from hypercoagulability, thrombosis, and hypertension associated with oxidative hemolysis and ACE2 deficiency, protecting cardiomyocytes from hypertrophy.
In my peer-reviewed paper released in June , I discussed in great detail, how melatonin can attenuate Ca2+ influx/calcium overload caused by SARS-CoV-2 viroporin ion channel activities.”