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Background Hypnic jerks are generally viewed as benign, transient motor events at sleep onset. In rare cases, however, they evolve into chronic, disruptive episodes that resist treatment and severely impair sleep. These persistent forms are often overlooked due to their similarity to benign analogs, limited clinical awareness, and lack of formal classification. We introduce Sleep-Onset Oscillatory Vasomotor Myoclonus (SOVM), a proposed condition characterized by pathologic hy

Novel Treaments

Agenda — Meeting #6 1. Drafting response to Neurosom email if we are to pursue 2. Erika meeting follow-up (no follow-up yet;...

Goals of Research Team Define what (excessive fragmentary) hypnic jerking is by developing and testing SOVM (Sleep-onset Oscillatory Vasomotor Myoclonus) hypothesis: It’s like the orchestra at sleep onset has lost its conductor- the gap junctions and ion channels can’t keep time. Gap junctions are like the conductor’s baton of the orchestra — keeping infraslow oscillations in time across neurons, astrocytes, vessels, and CSF flow. In the absence of the con

Voltage Gated Ion Channels and Sleep. The Journal of Membrane Biology (Volume 257, Issues 5–6, Pages 269–280) published December 2024, with online publication on October 1, 2024. A review of Ca²⁺, Na⁺, and K⁺ channel roles in sleep regulation across species; links dysfunction to sleep disorders and potential therapies. 10.1007/s00232-024-00325-0 Evidence shows Nav, K⁺, and especially Cav3.x channels regulate sleep-onset oscillations via thalamocortical circuits; disruption f

09/20/2025 Next-Gen Disease Screen (NGDS) & Related Tools Next-Gen Disease Screen (NGDS) • NGDS screens hundreds of genetic markers for potential disease risks. • Genetics is only one part of the picture—results should be considered along with your symptoms and family history when deciding whether to be concerned or inform your healthcare provider. • We reviewed how to interpret results, including the meaning of risk categories and confidence levels, which help guide possi

Thanks to “Team HJ” patients, we’ve added a major supporting article and an additional team member!

SOVM Meeting #5 — Minutes & Action Plan ​​ Attendees: • Dr. Giuseppe Lanza — neurology; sleep-related movement disorders;...

Septemeber 5, 2025 Dr. Erika says she would like to have a first meeting with folks who have their genetics returned to teach them what...

Article Integration Summary – SOVM Sleep-Onset Oscillatory Vasomotor Myoclonus 1. RAAS in PTSD: ACE and ARBs Reduce Symptoms (J Clin Psychiatry, 2012) ACE inhibition linked to reduced PTSD symptoms; implicates central RAAS in stress resilience and neurovascular modulation. In the case of SOVM, provides outside validation that RAAS signaling impacts CNS function, supporting SOVM's theory that low ACE/A2 worsens sleep-state regulation. https://www.psychiatrist.com/jcp/renin-ang

Erika Schwarz Taylor, PhD (Texas State University) — Genomics & Data Strategy Lead Genomic Data Analysis: Organize and interpret WGS,...

PLEASE DO NOT SHARE THIS BLOG Date: August 22, 2025 1) Eve’s Role & Interest • Title: Creator Marketing Manager at Sequencing.com •...

PLEASE DO NOT SHARE INFORMATION ELSEWHERE Meeting covered cohort composition, data strategy, IRB/ethics, funding considerations, a...

Below are highlights of what has worked with people from our Facebook community threads. It is not meant to be medical advice and should be reviewed by your medical practitioner. We have many similar patterns. However, each case seems to be slightly different. Information below is culled from close to two decades of data gathering. Its biggest influence, however, has been the data from trials involving our Facebook group over the last three years. Most of it can be summarized